In today’s digital economy, web-based integration of the enterprises to form an e-supply chain is a critical weapon for orchestrating the whole supply chain towards competitiveness. This paper intends to discuss the requirements for forming an e-supply chain from different perspectives, such as integration with the legacy systems, timing and prior presence of ERP (enterprise resources planning) systems, BPR (business process re-engineering) needs of internal and external business processes and business intelligence/decision support needs. A look at technical knowledge and structure to construct an e-supply chain is provided. Challenges involved in forming an e-supply chain are also briefly mentioned as a separate section in this paper. During the study, requirements are gathered by making a review of recent literature