The formation of Zagros Orogenic Belt of Iran, extending over 2000 km along the NW-SE direction, has been subjected to considerable controversy. Several geologists believe that this belt has been resulted by the subduction of Afro- Arabian plate underneath of the Iranian plate. This study presents an integrated analysis of remote sensing, geological and mineral occurrence data within a country scale GIS to test the hypothesis of subduction along this belt and to identify more precisely the subduction features inferred earlier by geologists. The interpretation of aeromagnetic data identifies several elongated subsurface ophiolitic rocks, which are believed to be the remnants of Neo-Thetys ocean that existed between the Afro-Arabian plate and Iran plate. Three sets of major NW, NE and N-S trending structures were identified by the processed aeromagnetic and AVHHR imagery. These structures control the occurrence of porphyry copper and epithermal precious metal mineralizations. Integrated analysis of all the available data presents a final map showing different elements of the subduction setting along the Zagros Orogenic belt. This study indicates that the suture zone, the surface expression of subducting Afro-Arabian plate beneath the Iran plate, is not located along the main Zagros thrust zone, as traditionally accepted by several geologists. It is inferred that the suture zone occurred at the southwestern boundary of the Urumieh-Dokhtar volcanic arc